IKK Inhibitor
IKK-16 (IKK Inhibitor VII)
CAS: 873225-46-8
Molecular Formula: C28H29N5OS
IKK Inhibitor - Names and Identifiers
IKK Inhibitor - Physico-chemical Properties
| Molecular Formula | C28H29N5OS |
| Molar Mass | 483.63 |
| Storage Condition | -20℃ |
| In vitro study | IKK-16 inhibited the expression of TNFα-stimulated adhesion molecules E-selectin, ICAM-1, and VCAM-1 in HUVEC cells. Although IKK-16 also had activity to inhibit IFNγ-induced β2 microglobulin or HLA-DR expression, its potency was 4-10 fold lower in these assays. |
| In vivo study | IKK-16 has Oral activity in rats and mice, and can inhibit the release of TNF-α induced by lipopolysaccharide in vivo, and can also inhibit neutrophil extravasation in peritonitis induced by sulfur colloid. |
IKK Inhibitor - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.068 ml | 10.338 ml | 20.677 ml |
| 5 mM | 0.414 ml | 2.068 ml | 4.135 ml |
| 10 mM | 0.207 ml | 1.034 ml | 2.068 ml |
| 5 mM | 0.041 ml | 0.207 ml | 0.414 ml |
Last Update：2024-01-02 23:10:35
IKK Inhibitor - Reference Information
| biological activity | IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor that acts on IKK-2,IKK complex and IKK-1. IC50 in cell-free test is 40 nM,70 nM and 200 nM respectively. IKK-16 can also inhibit the phosphorylation of LRRK2 Ser935 in cells and the kinase activity of LRRK2 in vitro experiments, with a corresponding IC50 value of 50 nM. |
| target | TargetValue IKK2 (Cell-free Assay) 40 nM IKK complex (Cell-free Assay) 70 nM IKK1 (Cell-free Assay) 200 nM |
| Target | Value |
| IKK2 (Cell-free assay) | 40 nM |
| IKK complex (Cell-free assay) | 70 nM |
| IKK1 (Cell-free assay) | 200 nM |
| in vitro study | IKK-16 inhibit the expression of TNFα-stimulated adhesion molecule E-selectin, ICAM-1, and VCAM-1 in HUVEC cells. Although IKK-16 also has the activity of inhibiting IFN γ-induced β2 microglobulin or HLA-DR expression, its titer is 4-10 times lower in these analyses. |
| in vivo studies | IKK-16 have oral activity on rats and mice, can inhibit the release of TNF-α induced by lipopolysaccharide in vivo, and can also inhibit neutrophil extravasation in peritonitis induced by thiodal. |
| use | [4-[(4-Benzo [B] thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-methanone is a potential novel iκ B kinase 2 (IKK2) inhibitor used in the treatment of various immune/inflammatory disorders. |
Last Update：2024-04-10 22:29:15
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Product Name: IKK-16 (IKK Inhibitor VII) Visit Supplier Webpage Request for quotationCAS: 873225-46-8
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
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Multiple SpecificationsSpot supply
Product Name: IKK 16 Visit Supplier Webpage Request for quotationCAS: 873225-46-8
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: IKK-16 (IKK Inhibitor VII) Visit Supplier Webpage Request for quotationCAS: 873225-46-8
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